COMBINED EFFECT OF GOLD NANOPARTICLES AND PROTON BEAMS IN IN VIVO EXPERIMENTS WITH INVERTEBRATES
https://doi.org/10.56304/S2079562925010166
EDN: PGHMXA
Abstract
The article analyzes the effectiveness of using spherical gold nanoparticles (AuNPs) with a size of 50 nm in combination with proton irradiation at a dose of 30 Gy (energy 150 MeV) in order to enhance the cytotoxic effect of binary therapy. The analysis was carried out in vivo experiments using the model invertebrate animal Daphnia magna. The biodistribution of AuNPs in the animal body was studied and the biochemical effect of the separate and combined action of the AuNPs with irradiation was analyzed. Accumulation of AuNPs in the intestine as well as in the eggs and embryos of the next generation was detected. Analysis of the level of free radicals and malondialdehyde revealed an increase in the cytotoxic effect of irradiation with nanoparticles.
About the Authors
D. T. Petrosova
Obninsk Institute of Nuclear Power Engineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute
D. V. Uskalova
Obninsk Institute of Nuclear Power Engineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute
Russian Federation
Russian Federation
O. V. Kuzmicheva
Obninsk Institute of Nuclear Power Engineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute
Russian Federation
Russian Federation
P. V. Shakhov
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
S. N. Koryakin
Obninsk Institute of Nuclear Power Engineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute;
Tsyb Medical Radiological Research Centre, National Medical Research Radiological Center, Ministry of Health
of the Russian Federation
Russian Federation
Russian Federation
E. I. Sarapultseva
Obninsk Institute of Nuclear Power Engineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
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For citations:
Petrosova D.T., Uskalova D.V., Kuzmicheva O.V., Shakhov P.V., Koryakin S.N., Sarapultseva E.I. COMBINED EFFECT OF GOLD NANOPARTICLES AND PROTON BEAMS IN IN VIVO EXPERIMENTS WITH INVERTEBRATES. Nuclear Physics and Engineering. 2025;16(5):681-686. (In Russ.) https://doi.org/10.56304/S2079562925010166. EDN: PGHMXA
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