EXPERIMENTAL STUDY OF 99MTC-METALLOTHIONEIN BIODISTRIBUTION IN INTACT ANIMALS
https://doi.org/10.56304/S2079562924050476
EDN: BHIYZU
Abstract
Metallothioneins are a special group of low-molecular-weight proteins with metal-binding properties, which make them promising chelators for the development of targeted radiopharmaceuticals, as well as with technetium-99m. The aim of this work was to investigate the biodistribution of 99mTc-metallothionein conjugate (99mTc-MT) in intact mice and compared it with unbound technetium-99m (Na99mTcO4). Low uptake of 99mTc-MT in the thyroid gland (1.20 ± 0.30%/g versus 267.2 ± 59.0%/g for Na99mTcO4) demonstrated high stability of 99mTc-MT in vivo. The 99mTc-MT complex was rapidly eliminated from the bloodstream through the kidneys and was characterized by a reduced uptake in most organs and tissues compared to Na99mTcO4.
About the Authors
V. K. Tishchenko
Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. A. Lebedeva
Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. V. Fedorova
Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
S. P. Orlenko
Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
N. G. Minaeva
Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
P. V. Shegai
Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation;
National Medical Research Radiological Centre, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
S. A. Ivanov
Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation;
Рeoples’ Friendship University of Russia (RUDN University)
Russian Federation
Russian Federation
A. D. Kaprin
National Medical Research Radiological Centre, Ministry of Health of the Russian Federation;
Рeoples’ Friendship University of Russia (RUDN University);
Hertsen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation,
Russian Federation
Russian Federation
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Review
For citations:
Tishchenko V.K., Lebedeva A.A., Fedorova A.V., Orlenko S.P., Minaeva N.G., Shegai P.V., Ivanov S.A., Kaprin A.D. EXPERIMENTAL STUDY OF 99MTC-METALLOTHIONEIN BIODISTRIBUTION IN INTACT ANIMALS. Nuclear Physics and Engineering. 2025;16(3):379-382. (In Russ.) https://doi.org/10.56304/S2079562924050476. EDN: BHIYZU
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