CARBON NANODOTS OBTAINED BY MICROWAVE SYNTHESIS: PHYSICAL PROPERTIES AND ASSESSMENT OF CYTOTOXICITY ON A MODEL OF GLIOBLASTOMA AND EMBRYONAL KIDNEY IN VITRO
https://doi.org/10.56304/S2079562924050270
EDN: TTAWAV
Abstract
Carbon nanodots (CNDs) produced by liquid-based synthesis methods are an example of a biocompatible, nontoxic nanomaterial with physical properties promising for various applications. In our work, CNDs were obtained from organic precursors by express synthesis in a microwave reactor followed by purification in isopropyl alcohol and were studied by transmission electron microscopy, infrared spectroscopy, and optical absorption spectroscopy in the ultraviolet–visible–near-infrared range, as well as photoluminescence. Cytotoxicity assessment was performed on in vitro models of glioblastoma and embryonic kidney. The obtained results indicate the prospects of the used method of CND synthesis in the production of nanomaterials for biomedical luminescent diagnostics.
About the Authors
A. N. Kopylov
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
D. U. Musaeva
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
V. V. Kudelkina
Avtsyn Research Institute of Human Morphology, Petrovskii Russian Scientific Center for Surgery
Russian Federation
Russian Federation
A. V. Syui
Moscow Institute of Physics and Technology
Russian Federation
Russian Federation
A. M. Kosyreva
Avtsyn Research Institute of Human Morphology, Petrovskii Russian Scientific Center for Surgery
Russian Federation
Russian Federation
A. I. Alekseeva
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
A. Yu. Zakharkiv
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
V. Yu. Timoshenko
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Moscow State University
Russian Federation
Russian Federation
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Review
For citations:
Kopylov A.N., Musaeva D.U., Kudelkina V.V., Syui A.V., Kosyreva A.M., Alekseeva A.I., Zakharkiv A.Yu., Timoshenko V.Yu. CARBON NANODOTS OBTAINED BY MICROWAVE SYNTHESIS: PHYSICAL PROPERTIES AND ASSESSMENT OF CYTOTOXICITY ON A MODEL OF GLIOBLASTOMA AND EMBRYONAL KIDNEY IN VITRO. Nuclear Physics and Engineering. 2025;16(3):361-365. (In Russ.) https://doi.org/10.56304/S2079562924050270. EDN: TTAWAV
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