EFFECT OF COLD ATMOSPHERIC PRESSURE GAS-DISCHARGE PLASMA ON CELLULAR MODEL OF PARAMECIUM CAUDATUM IN THE STUDY OF THE ANTIOXIDANT PROPERTIES OF MEXIDOL
https://doi.org/10.56304/S2079562924050014
EDN: VEBBKS
Abstract
The cytoprotective properties of mexidol were studied under the influence of argon and helium gas-discharge cold plasma of atmospheric pressure on Paramecium caudatum cell culture. It has been shown that mexidol exhibits strong antioxidant properties and practically completely eliminates the negative effects of oxidative stress, retaining almost 100% of the initial number of cells. The data obtained demonstrate a wide range of behavioral responses of Paramecium caudatum, which confirms their practical value as model objects for pharmacological and toxicological studies and the use of gas-discharge cold plasma makes it possible to exclude the direct oxidative effect of hydrogen peroxide (the standard model of oxidative stress) on the studied drugs and to increase the reliability of toxicological studies.
About the Authors
G. N. Abrashitov
Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
G. A. Gruzdev
Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
V. G. Yakunin
Faculty of Physics, Lomonosov Moscow State University
Russian Federation
Russian Federation
V. P. Savinov
Faculty of Physics, Lomonosov Moscow State University
Russian Federation
Russian Federation
P. V. Karpukhina
Faculty of Biology, Lomonosov Moscow State University;
Semenov Federal Research Centre of Chemical Physics, Russian Academy of Sciences
Russian Federation
Russian Federation
V. Yu. Timoshenko
Faculty of Physics, Lomonosov Moscow State University;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
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Review
For citations:
Abrashitov G.N., Gruzdev G.A., Yakunin V.G., Savinov V.P., Karpukhina P.V., Timoshenko V.Yu. EFFECT OF COLD ATMOSPHERIC PRESSURE GAS-DISCHARGE PLASMA ON CELLULAR MODEL OF PARAMECIUM CAUDATUM IN THE STUDY OF THE ANTIOXIDANT PROPERTIES OF MEXIDOL. Nuclear Physics and Engineering. 2025;16(3):355-360. (In Russ.) https://doi.org/10.56304/S2079562924050014. EDN: VEBBKS
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