GD-DOPED CERIUM OXIDE NANOPARTICLES AS A NEW MRI CONTRAST AGENT: ANALYSIS OF PROPERTIES AND BIOCOMPATIBILITY
https://doi.org/10.56304/S2079562924050245
EDN: QTZMWR
Abstract
The paper presents the results of a study of a new folic acid functionalized nanocomposite cerium oxide based gadolinium-doped material as a promising material as a new MRI contrast agent. As part of this work, we carried out a comprehensive analysis of their characteristics, colloidal stability, and MRI response, as well as a comprehensive analysis of its cytotoxicity on a U251 human glioblastoma cell culture in vitro. It has been shown that the synthesized nanocomposite causes a dose-dependent cytotoxic effect on human glioblastoma cells, causing the development of intracellular oxidative stress and subsequent initiation of the apoptosis process. Such a nanocomposite is promising for the development of a new theranostic agent based on it, which has not only MRI-contrasting properties, but also a pronounced redox activity, which ensures its cytotoxic effect and therapeutic activity in the cell.
About the Authors
D. D. Kolmanovich
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
E. A. Mysina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
I. V. Savintseva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
T. O. Kozlova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
N. N. Chukavin
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
V. K. Ivanov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Kolmanovich D.D., Mysina E.A., Savintseva I.V., Kozlova T.O., Chukavin N.N., Ivanov V.K., Popov A.L. GD-DOPED CERIUM OXIDE NANOPARTICLES AS A NEW MRI CONTRAST AGENT: ANALYSIS OF PROPERTIES AND BIOCOMPATIBILITY. Nuclear Physics and Engineering. 2025;16(2):259-264. (In Russ.) https://doi.org/10.56304/S2079562924050245. EDN: QTZMWR
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