Interaction of Human Serum and Plasma Proteins with Polyelectrolyte Microcapsules of Different Structures

Abstract

The study of the interactions between systems for targeted drug delivery and components of human biological fluids is one of the actual directions in the development of personalized therapy strategies for a variety of human diseases. Encapsulation of drugs in microcarriers enables drug intactness and their prolonged release in their target organ. The structure and surface properties of microcarriers determine their overall biocompatibility and features of their interaction with biomolecules. In the presented work, the core/polyelectrolyte shell microparticles and polyelectrolyte microcapsules with a dissolved core, which have different degrees of structural rigidity, were obtained. Their interaction with human serum and plasma proteins was analyzed. The obtained results demonstrate that the proteins that bind to the surface of polyelectrolyte microparticles with different structures have a distinctive profile.