Design of SAHA-Loaded PLGA Nanoparticles Aimed to Use in Breast Cancer Combination Therapy
https://doi.org/10.56304/S2079562924050191
EDN: PNBYNU
Abstract
In present work we have developed a method for synthesis of vorinostat-loaded nanoparticles based on a copolymer of lactic and glycolic acids. We optimized the method using Box-Banken design. The nanoparticles synthesized via the optimized technology had a spherical shape, which was confirmed by transmission electron microscopy. An average diameter of the nanoparticles was 196 nm, a polydispersity index was 0.089, and a zeta potential was –22.3 mV. The drug loading in the nanoparticles was 0.91 wt %, and the analysis was performed by high-performance liquid chromatography.
About the Authors
I. A. Gulyaev
Emanuel Institute of Biochemical Physics , Russian Academy of Sciences
Russian Federation
Russian Federation
M. B. Sokol
Emanuel Institute of Biochemical Physics , Russian Academy of Sciences
Russian Federation
Russian Federation
M. A. Klimenko
Emanuel Institute of Biochemical Physics , Russian Academy of Sciences
Russian Federation
Russian Federation
M. R. Mollaeva
Emanuel Institute of Biochemical Physics , Russian Academy of Sciences
Russian Federation
Russian Federation
N. G. Yabbarov
Emanuel Institute of Biochemical Physics , Russian Academy of Sciences
Russian Federation
Russian Federation
M. V. Chirkina
Emanuel Institute of Biochemical Physics , Russian Academy of Sciences
Russian Federation
Russian Federation
E. D. Nikolskaya
Emanuel Institute of Biochemical Physics , Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Gulyaev I.A., Sokol M.B., Klimenko M.A., Mollaeva M.R., Yabbarov N.G., Chirkina M.V., Nikolskaya E.D. Design of SAHA-Loaded PLGA Nanoparticles Aimed to Use in Breast Cancer Combination Therapy. Nuclear Physics and Engineering. 2024;15(5):483-488. (In Russ.) https://doi.org/10.56304/S2079562924050191. EDN: PNBYNU
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