Multilayered Polymer Capsules for Targeted Delivery of Antitumor Compounds
https://doi.org/10.56304/S207956292405021X
EDN: CLTYKV
Abstract
The development of controlled targeted drug delivery systems for personalized cancer therapy is one of the most important tasks of modern medicine. Controlled delivery and releasing of antitumor drugs provide a reduction in their toxicity to normal human cells and reduce the severity of side effects of cancer therapy. Multilayer polymeric capsules (MPCs) are promising potential candidates for the development of delivery systems based on them. MPCs are produced by layer-by-layer adsorption of oppositely charged polyelectrolytes on the surface of a charged microsubstrate of spherical shape. This method allows to obtain MPCs of different structures and functionalize them with antitumor agents and biomolecules for cancer targeted delivery. The paper presents the main stages of the production of MPCs and analyzes the efficiency of loading the anticancer drug doxorubicin (DOX) within the MPCs using passive diffusion.
About the Authors
D. V. Kalenichenko
Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-Ardenne
Russian Federation
Russian Federation
G. O. Nifontova
Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-Ardenne
Russian Federation
Russian Federation
I. S. Kriukova
Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
A. Sukhanova
Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-Ardenne
Russian Federation
Russian Federation
I. Nabiev
Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-Ardenne
Russian Federation
Russian Federation
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Review
For citations:
Kalenichenko D.V., Nifontova G.O., Kriukova I.S., Sukhanova A., Nabiev I. Multilayered Polymer Capsules for Targeted Delivery of Antitumor Compounds. Nuclear Physics and Engineering. 2024;15(5):478-482. (In Russ.) https://doi.org/10.56304/S207956292405021X. EDN: CLTYKV
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