Accumulation of Tritium and Other Undesirable β-Emitting Radionuclides in the Production of Radiopharmaceuticals for PET Diagnostics
https://doi.org/10.56304/S2079562923030090
Abstract
The article deals with the problem of formation of undesirable β-emitting radionuclides (RNs) in the production of radiopharmaceuticals for PET diagnostics. It is found that tritium is the main trace RN formed by the reaction 18O(p,t)16O during irradiation of water [18O]H2O with protons. Other trace β emitters in water accumulate mainly as a result of leaching of activated target wall materials. The possibility of using the activity of tritium in water [18O]H2O as an indicator of its re-enrichment is shown. The necessity of controlling the content of trace β-emitting RNs in intermediate products, production waste, and final radiopharmaceuticals is demonstrated.
About the Authors
S. D. Brinkevich
Belarusian State University, Minsk, 220030 Belarus
Federal Center of Nuclear Medicine Projects Design and Development, Federal
Biomedical Agency, Branch of Zavod Medradiopreparat, Moscow, 123098 Russia
Belarus
Belarus
D. I. Brinkevich
Belarusian State University, Minsk, 220030 Belarus
Belarus
Belarus
A. I. Kiyavitskaya
International Sakharov Environmental Institute, Belarusian State University, Minsk, 220070 Belarus
Belarus
Belarus
А. N. Kiyko
Belarusian State Institute of Metrology, Minsk, 220053 Belarus
Belarus
Belarus
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Review
For citations:
Brinkevich S.D., Brinkevich D.I., Kiyavitskaya A.I., Kiyko А.N. Accumulation of Tritium and Other Undesirable β-Emitting Radionuclides in the Production of Radiopharmaceuticals for PET Diagnostics. Nuclear Physics and Engineering. 2024;15(2):177–183. (In Russ.) https://doi.org/10.56304/S2079562923030090
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