Development and Creation of Equipment for Simultaneous Hyperthermia and Radiation Therapy of Malignant Neoplasms
https://doi.org/10.56304/S2079562922030253
Abstract
A series of applicators based on phased array antenna (PAA) has been created for electromagnetic high-frequency hyperthermia and simultaneous radiation therapy of tumors characterized by high transparency for gamma radiation. Studies have been carried out on the stability of the material of the main element of the microstrip emitter its antenna to the ionizing radiation. Possible seven sizes of applicator operating at a frequency of 434 MHz were considered. The distribution of the square of the component of the electrical part of the electromagnetic field emitted by the applicator – SAR (Specific Absorption Rate) in the plane of the applicator aperture was measured. Experimental results of SAR distribution in the plane of the applicator aperture from single modules for different phases of electromagnetic fields of excitation are presented. The main parameters of the Quality Standard in oncological hyperthermia, which should be achieved in the treatment of cancer patients with a specific list of nosological forms of neoplasms, are considered.
About the Authors
V. V. Kosterev
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
Moscow, 115409
V. N. Masokhin
JSC “NPP “ISTOK” named after A.I. Shokin”
Russian Federation
Russian Federation
Fryazino, 141190
References
1. Alexandrov N.N., Savchenko N.Y., Fradkin S.Z. // Application of Hyperthermia and Hyperglycemia in Treatment of Malignant Tumors. 1980. Moscow: Meditsina (in Russian).
2. Field S.B., Hand J.W. // An Introduction to the Practical Aspects of Clinical Hyperthermia. 1990. London: Taylor and Francis.
3. Van der Zee J.D., Gonzales-Gonzales D., van Rhoon G. // Lancet. 2000. V. 335 (9210). P. 1119–1125.
4. Van Rhoon G.C., Rietveld P.J.M., van der Zee J. // Int. J. Hyperthermia. 1998. V. 14 (1). P. 13-27.
5. Gopal M.K., Cetas T.C. // IEEE Trans. Microwave Theory Tech. 1993. V. MTT-41. P. 431–437.
6. Staufer P.R., Rosseto F., Leoncini M. // IEEE Trans. Biomed. Eng. 1998. V. BME-45. P. 605–613.
7. Myerson R.J., Straube W.L, Taylor M. // Proc. 9th Int. Congress of Hyperthermic Oncology (ICHO). 2004. P. 80.
8. Myerson R.J., Straube W.L, Moros E.G. // Proc. 9th Int. Congress of Hyperthermic Oncology (ICHO). 2004. P. 90.
9. Gelvich E.A. // Proc. 17th Ann. Meeting of the European Society for Hyperthermic Oncology (ESHO). 1998. P. 23.
10. Аверкин А.Н., Вайнсон А.А., Гельвич Э.А., Горлачев Г.Е., Званцев А.А., Климанов В.А., Костерев В.В., Крамер-Агеев Е.А., Мазохин В.Н., Мещерикова В.В., Мишулина О.А., Могиленец Н.Н., Синяговский В.И., Смирнов В.В. // Ядерная физика и инжиниринг. 2010. Т. 1 (3). С. 241–288.
11. Prior M.V., Lumori M.L.D., Hand J.W. // IEEE Trans. Biomed. Eng. 1995. V. BME-42. P. 694–698.
12. Gopal M.K., Hand J.W., Lumori M.L.D. // Int. J. Hyperthermia. 1992. V. 8. P. 227–240.
13. Gelvich E.A., Kolmakov D.N., V.N. Mazokhin V.N. // COMAC-BME Hypertherm. Bull. 1992. No. 10. P. 66–72.
14. Gelvich E.A., Mazokhin V.N., Troshin I.I. // Proc. 2nd Int. Scientific Meeting on Microwave in Medicine. Rome, Italy. 1993. P. 71–74.
15. Gelvich E.A., Mazokhin V.N., Tkachev S.L. // Proc. 7th Int. Congress on Hyperthermia Oncology. Rome, Italy. 1996. P. 449–451.
16. Lamaitre G. G., van Dijk J.D.P., Gelvich E.A. // Int. J. Hyperthermia. 1996. V. 12 (2). P. 255–269.
17. Marchal C., Tekieli P., Niederst C. // Proc. 15th Ann. Meeting of European Society for Hyperthermic Oncology (ESHO). Oxford, UK. 1995. P. 9.
18. Van Wieringen N., Gelvich E.A., van Dijk J.D.P. // Proc. 18th Ann. Meeting of the European Society for Hyperthermic Oncology (ESHO). Rotterdam, Netherlands. 1999. P. 82.
19. Meinke H., Gundlach F.W. // Taschenbuch der Hochfrequenztechnik. 1956. Munich, Germany.
20. Gelvich E.A., Mazokhin V.N. // Int. J. Hyperthermia. 2000. V. 16 (2). P. 113–128.
21. Mazokhin V.N., Kolmakov D.N., Lucheyov N.A. // Int. J. Hyperthermia. 1999. V. 15 (4). P. 309–329.
22. Dewhirst M.W., Phillips T.L., Simulski T.V. // Int. J. Radiation Oncol. Biol. Phys. 1990. V. 18. P. 1249–1259.
23. Kosterev V.V., Kramer-Ageev E.A., Mazokhin V.N., van Rhoon G.C., Crezee J. // Int. J. Hyperthermia. 2015. V. 31 (4). P. 443–452.
Review
For citations:
Kosterev V.V., Masokhin V.N. Development and Creation of Equipment for Simultaneous Hyperthermia and Radiation Therapy of Malignant Neoplasms. Nuclear Physics and Engineering. 2022;13(4):403-416. (In Russ.) https://doi.org/10.56304/S2079562922030253
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